ea0020p668 | Steroid Receptors | ECE2009
Zajac Jeffrey
, Rana K
, Fam B
, Andrikopoulos S
, MacLean Helen
We have used an androgen receptor knockout (ARKO) mouse model with an in-frame deletion of the 2nd zinc finger of the DNA binding domain, which abolishes the genomic actions of the AR to investigate androgen regulation of fat mass. At 12 weeks of age, ARKO males have increased adiposity compared to wildtype (WT) males, with subcutaneous fat mass increased by 75% (P<0.001, n≥17/group) and infrarenal fat mass increased by 36% (P<0.05, n&...